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KMID : 0829320140170020050
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Korean Journal of Clinical Microbiology
2014 Volume.17 No. 2 p.50 ~ p.57
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Characterization of Salmonella spp. Clinical Isolates in Gyeongsangbuk-do Province, 2012 to 2013Background: Extended-spectrum cephalosporins and fluoroquinolones are important antimicrobials for treating invasive salmonellosis, and emerging resistance to these antimicrobials is of paramount concern.
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Kwon O-Geun
Kim Jin-Seok
Kim Gou-Ok
Lee Chang-Il
Jeong Kwang-Hyeon
Kin Jun-Young
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Abstract
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Background: Extended-spectrum cephalosporins and fluoroquinolones are important antimicrobials for treating invasive salmonellosis, and emerging resistance to these antimicrobials is of paramount concern.
Methods: A total of 30 Salmonella spp. clinical isolates recovered in Gyeongsangbuk-do from 2012 to2013 were characterized using antibiotic resistance profiles and pulsed-field gel electrophoresis (PFGE).
Results: A high prevalence of multidrug-resistant isolates,mainly showing an ampicillin, nalidixic acid,chloramphenicol resistance pattern, was observed. Four extended-spectrum β-lactamase (ESBL)-producing isolates (3 CTX-M-15 isolates and 1 CTX-M-27 isolate)were found. The blaCTX-M-27 gene was carried byan IncF conjugative plasmid in the S. Infantis isolate.The blaCTX-M-15 gene were carried by an IncF (2 isolates) or IncHI2 (1 isolate) conjugative plasmid in S.Enteritidis. In addition, a single mutation of GyrA, Ser83Thr (1 isolates), Asp87Tyr (9 isolates), Asp87Gly (4 isolates), and Asp87Leu (3 isolates), was detected in nalidixic acid-resistant Salmonella spp. isolates. XbaI PFGE analysis of all isolates revealed more than 19 different pulsotypes. The most common S.Enteritidis PFGE pattern (SEGX01.003) was associated with a larger number of cases of invasive salmonellosis than all other patterns.
Conclusion: The information from our study can assist in source attribution, outbreak investigations, and tailoring of interventions to maximize disease prevention.
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